1 Background

Alternative DNA structures, such as Z-DNA, G-quadruplexes, and mirror repeats, have shown potential involvement in cancer etiology. Research suggests that non-B DNA-forming sequences can promote genetic instability in human cancer genomes, indicating their potential role in cancer and other genetic diseases.

Although several non-B prediction databases have been published between 2008-2013, they do not provide the ability to analyze and visualize non-B data in the context of cancer gene signature sets, which is crucial for studying their role in cancer development.