9 Overview

The Motif Screen module within NBBC is designed for non-B motif-level exploration, allowing users to select motifs from the gene screen analyses for insight into their heterogeneity with respect to user-selected sequence features such as length, %G, and %A.

To facilitate this exploration, the motif screen module offers motif sequence-level, unsupervised clustering of features. For example, when exploring motif selection from mirror repeats, length and %G can be two major factors to consider. The clustering of non-B forming sequences based on the selected sequence features can be viewed at both the gene-level (gene-informed) and non-B structure level (non-B informed).

Within each visualization, users can click on any dot or circle to select the sequences of interest. The selected data points are then output in a table format, from which users may optionally include the flank regions of motif sequences whose lengths can also be user-defined for further downstream exploration.

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