7 Data Source Options
7.1 Our curation process
From these datasources we only obtained TTS sequences. Each sequence was mapped to the Gencode v44 (Hg38) primary assembly to find that TTS’s location(s) in the genome.
7.2 TFO Search
URL:https://utw10685.utweb.utexas.edu/tfo/about.php
TTS Sequence Source: https://utw10685.utweb.utexas.edu/tfo/pub/wu/1/TFO_targets_Hs.txt.zip
Web Search Engine Publication:
Gaddis SS, Wu Q, Thames HD, DiGiovanni J, Walborg EF, MacLeod MC, Vasquez KM. A web-based search engine for triplex-forming oligonucleotide target sequences. Oligonucleotides. 2006 Summer;16(2):196-201. doi: 10.1089/oli.2006.16.196. PMID: 16764543.
Original Data Publication:
Wu Q, Gaddis SS, MacLeod MC, Walborg EF, Thames HD, DiGiovanni J, Vasquez KM. High-affinity triplex-forming oligonucleotide target sequences in mammalian genomes. Mol Carcinog. 2007 Jan;46(1):15-23. doi: 10.1002/mc.20261. PMID: 17013831.
7.3 TTSMI
URL:https://ttsmi.bii.a-star.edu.sg/
TTS Sequence Source: Personal Communications
Data Publication:
Jenjaroenpun P, Chew CS, Yong TP, Choowongkomon K, Thammasorn W, Kuznetsov VA. The TTSMI database: a catalog of triplex target DNA sites associated with genes and regulatory elements in the human genome. Nucleic Acids Res. 2015 Jan;43(Database issue):D110-6. doi: 10.1093/nar/gku970. Epub 2014 Oct 16. PMID: 25324314; PMCID: PMC4384029.